Publications

all Publications


Papastavrou, N., Horning, D.P., Joyce, G.F. RNA-catalyzed evolution of catalytic RNA. (2024) Proceedings of the National Academy of Sciences of the United States of America. 121(11):e2321592121. DOI: 10.1073/pnas.2321592121

+ expand abstract

Kakoti, A., Joyce, G.F. RNA Polymerase Ribozyme That Recognizes the Template-Primer Complex through Tertiary Interactions. (2023) Biochemistry. DOI: 10.1021/acs.biochem.3c00091

+ expand abstract

Menichelli, E., Lam, B.J., Wang, Y., Wang, V.S., Shaffer, J., Tjhung, K.F., Bursulaya, B., Nguyen, T.N., Vo, T., Alper, P.B., McAllister, C.S., Jones, D.H., Spraggon, G., Michellys, P.Y., Joslin, J., Joyce, G.F., Rogers, J. Discovery of small molecules that target a tertiary-structured RNA. (2022) Proceedings of the National Academy of Sciences of the United States of America. 119(48):e2213117119. DOI: 10.1073/pnas.2213117119

+ expand abstract

Bare, G.A.L., Joyce, G.F. Cross-Chiral, RNA-Catalyzed Exponential Amplification of RNA. (2021) Journal of the American Chemical Society. DOI: 10.1021/jacs.1c09233

+ expand abstract

Portillo, X., Huang, Y.T., Breaker, R.R., Horning, D.P., Joyce, G.F. Witnessing the structural evolution of an RNA enzyme. (2021) Elife. 10. DOI: 10.7554/eLife.71557

+ expand abstract

Setterholm, N.A., Haratipour, P., Kashemirov, B.A., McKenna, C.E., Joyce, G.F. Kinetic Effects of β,γ-Modified Deoxynucleoside 5′-Triphosphate Analogues on RNA-Catalyzed Polymerization of DNA. (2020) Biochemistry. DOI: 10.1021/acs.biochem.0c00779

+ expand abstract

Tjhung, K.F., Sczepanski, J.T., Murtfeldt, E.R., Joyce, G.F. RNA-Catalyzed Cross-Chiral Polymerization of RNA. (2020) Journal of the American Chemical Society. DOI: 10.1021/jacs.0c05635

+ expand abstract

Salditt, A., Keil, L.M.R., Horning, D.P., Mast, C.B., Joyce, G.F., Braun, D. Thermal Habitat for RNA Amplification and Accumulation. (2020) Phys. Rev. Lett. 125(4):048104. DOI: 10.1103/PhysRevLett.125.048104

+ expand abstract

Tjhung, K.F., Shokhirev, M.N., Horning, D.P., Joyce, G.F. An RNA polymerase ribozyme that synthesizes its own ancestor. (2020) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1914282117

+ expand abstract

Horning, D.P., Bala, S., Chaput, J.C., Joyce, G.F. RNA-Catalyzed Polymerization of Deoxyribose, Threose, and Arabinose Nucleic Acids. (2019) ACS Synthetic Biology. 8(5):955-961. DOI: 10.1021/acssynbio.9b00044

+ expand abstract

Pressman, A.D., Liu, Z., Janzen, E., Blanco, C., Müller, U.F., Joyce, G.F., Pascal, R., Chen, I.A. Mapping a systematic ribozyme fitness landscape reveals a frustrated evolutionary network for self-aminoacylating RNA. (2019) Journal of the American Chemical Society. DOI: 10.1021/jacs.8b13298

+ expand abstract

Joyce, G.F., Szostak, J.W. Protocells and RNA Self-Replication. (2018) Cold Spring Harbor Perspectives in Biology. 10(9). DOI: 10.1101/cshperspect.a034801

+ expand abstract

Samanta, B., Horning, D.P., Joyce, G.F. 3′-End labeling of nucleic acids by a polymerase ribozyme. (2018) Nucleic Acids Research. DOI: 10.1093/nar/gky513

+ expand abstract

Joyce, G.F., Samanta, B. A reverse transcriptase ribozyme. (2017) Elife. 6. DOI: 10.7554/eLife.31153

+ expand abstract

Olea, C., Joyce, G.F. Real-Time Detection of a Self-Replicating RNA Enzyme. (2016) Molecules. 21(10). DOI: 10.3390/molecules21101310

+ expand abstract

Horning, D.P., Joyce, G.F. Amplification of RNA by an RNA polymerase ribozyme. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(35):9786-91. DOI: 10.1073/pnas.1610103113

+ expand abstract

Sczepanski, J.T., Joyce, G.F. Specific Inhibition of MicroRNA Processing Using L-RNA Aptamers. (2015) Journal of the American Chemical Society. 137(51):16032-7. DOI: 10.1021/jacs.5b06696

+ expand abstract

Joyce, G.F. Reflections of a Darwinian Engineer. (2015) Journal of Molecular Evolution. 81(5-6):146-9. DOI: 10.1007/s00239-015-9724-6


Olea, C., Weidmann, J., Dawson, P.E., Joyce, G.F. An L-RNA Aptamer that Binds and Inhibits RNase. (2015) Chemistry & Biology. 22(11):1437-1441. DOI: 10.1016/j.chembiol.2015.09.017

+ expand abstract

Olea, C., Joyce, G.F. Ligand-dependent exponential amplification of self-replicating RNA enzymes. (2015) Meth. Enzymol. 550:23-39. DOI: 10.1016/bs.mie.2014.10.030

+ expand abstract

Sczepanski, J.T., Joyce, G.F. A cross-chiral RNA polymerase ribozyme. (2014) Nature. 515(7527):440-2. DOI: 10.1038/nature13900

+ expand abstract

Petrie, K.L., Joyce, G.F. Limits of neutral drift: lessons from the in vitro evolution of two ribozymes. (2014) J. Mol. Evol. 79(3-4):75-90. DOI: 10.1007/s00239-014-9642-z

+ expand abstract

Breaker, R.R., Joyce, G.F. The expanding view of RNA and DNA function. (2014) Chemistry & Biology. 21(9):1059-65. DOI: 10.1016/j.chembiol.2014.07.008

+ expand abstract

Robertson, M.P., Joyce, G.F. Highly efficient self-replicating RNA enzymes. (2014) Chemistry & Biology. 21(2):238-45. DOI: 10.1016/j.chembiol.2013.12.004

+ expand abstract

Sczepanski, J.T., Joyce, G.F. Binding of a structured D-RNA molecule by an L-RNA aptamer. (2013) Journal of the American Chemical Society. 135(36):13290-3. DOI: 10.1021/ja406634g

+ expand abstract

Ferretti, A.C., Joyce, G.F. Kinetic properties of an RNA enzyme that undergoes self-sustained exponential amplification. (2013) Biochemistry. 52(7):1227-35. DOI: 10.1021/bi301646n

+ expand abstract

Sczepanski, J.T., Joyce, G.F. Synthetic evolving systems that implement a user-specified genetic code of arbitrary design. (2012) Chemistry & Biology. 19(10):1324-32. DOI: 10.1016/j.chembiol.2012.08.017

+ expand abstract

Joyce, G.F. Bit by bit: the Darwinian basis of life. (2012) PLOS Biology. 10(5):e1001323. DOI: 10.1371/journal.pbio.1001323

+ expand abstract

Olea, C., Horning, D.P., Joyce, G.F. Ligand-dependent exponential amplification of a self-replicating L-RNA enzyme. (2012) Journal of the American Chemical Society. 134(19):8050-3. DOI: 10.1021/ja302197x

+ expand abstract

Joyce, G.F. Evolution. Toward an alternative biology. (2012) Science. 336(6079):307-8. DOI: 10.1126/science.1221724


Lam, B.J., Joyce, G.F. An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification. (2011) Journal of the American Chemical Society. 133(9):3191-7. DOI: 10.1021/ja111136d

+ expand abstract

Petrie, K.L., Joyce, G.F. Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs. (2010) Nucleic Acids Research. 38(22):8095-104. DOI: 10.1093/nar/gkq685

+ expand abstract

Paegel, B.M., Joyce, G.F. Microfluidic compartmentalized directed evolution. (2010) Chemistry & Biology. 17(7):717-24. DOI: 10.1016/j.chembiol.2010.05.021

+ expand abstract

Joyce, G.F. Evolution in an RNA world. (2009) Cold Spring Harbor Symposia on Quantitative Biology. 74:17-23. DOI: 10.1101/sqb.2009.74.004

+ expand abstract

Voytek, S.B., Joyce, G.F. Niche partitioning in the coevolution of 2 distinct RNA enzymes. (2009) Proceedings of the National Academy of Sciences of the United States of America. 106(19):7780-5. DOI: 10.1073/pnas.0903397106

+ expand abstract

Lam, B.J., Joyce, G.F. Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA. (2009) Nature Biotechnology. 27(3):288-92. DOI: 10.1038/nbt.1528

+ expand abstract

Lincoln, T.A., Joyce, G.F. Self-sustained replication of an RNA enzyme. (2009) Science. 323(5918):1229-32. DOI: 10.1126/science.1167856

+ expand abstract

Paegel, B.M., Joyce, G.F. Darwinian evolution on a chip. (2008) PLOS Biology. 6(4):e85. DOI: 10.1371/journal.pbio.0060085

+ expand abstract

Joyce, G.F. Obituary: Leslie Orgel (1927-2007). (2007) Nature. 450(7170):627. DOI: 10.1038/450627a


Voytek, S.B., Joyce, G.F. Emergence of a fast-reacting ribozyme that is capable of undergoing continuous evolution. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(39):15288-93. DOI: 10.1073/pnas.0707490104

+ expand abstract

Joyce, G.F. Forty years of in vitro evolution. (2007) Angew. Chem. Int. Ed. Engl. 46(34):6420-36. DOI: 10.1002/anie.200701369

+ expand abstract

Joyce, G.F. Structural biology. A glimpse of biology’s first enzyme. (2007) Science. 315(5818):1507-8. DOI: 10.1126/science.1140736


Paegel, B.M., Grover, W.H., Skelley, A.M., Mathies, R.A., Joyce, G.F. Microfluidic serial dilution circuit. (2006) Analytical Chemistry. 78(21):7522-7. DOI: 10.1021/ac0608265

+ expand abstract

Cadwell, R.C., Joyce, G.F. Mutagenic PCR. (2006) CSH Protoc. 2006(1). DOI: 10.1101/pdb.prot4143


Paul, N., Springsteen, G., Joyce, G.F. Conversion of a ribozyme to a deoxyribozyme through in vitro evolution. (2006) Chemistry & Biology. 13(3):329-38. DOI: 10.1016/j.chembiol.2006.01.007

+ expand abstract

Oberhuber, M., Joyce, G.F. A DNA-templated aldol reaction as a model for the formation of pentose sugars in the RNA world. (2005) Angewandte Chemie. 44(46):7580-3. DOI: 10.1002/anie.200503387


Johns, G.C., Joyce, G.F. The promise and peril of continuous in vitro evolution. (2005) J. Mol. Evol. 61(2):253-63. DOI: 10.1007/s00239-004-0307-1

+ expand abstract

Paul, N., Joyce, G.F. Minimal self-replicating systems. (2004) Current Opinion in Chemical Biology. 8(6):634-9. DOI: 10.1016/j.cbpa.2004.09.005

+ expand abstract

Kim, D.E., Joyce, G.F. Cross-catalytic replication of an RNA ligase ribozyme. (2004) Chemistry & Biology. 11(11):1505-12. DOI: 10.1016/j.chembiol.2004.08.021

+ expand abstract

Springsteen, G., Joyce, G.F. Selective derivatization and sequestration of ribose from a prebiotic mix. (2004) Journal of the American Chemical Society. 126(31):9578-83. DOI: 10.1021/ja0483692

+ expand abstract

Joyce, G.F. Directed evolution of nucleic acid enzymes. (2004) Annual Review of Biochemistry. 73:791-836. DOI: 10.1146/annurev.biochem.73.011303.073717

+ expand abstract

Shih, W.M., Quispe, J.D., Joyce, G.F. A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron. (2004) Nature. 427(6975):618-21. DOI: 10.1038/nature02307

+ expand abstract

Kühne, H., Joyce, G.F. Continuous in vitro evolution of ribozymes that operate under conditions of extreme pH. (2003) J. Mol. Evol. 57(3):292-8. DOI: 10.1007/s00239-003-2480-z

+ expand abstract

Kumar, R.M., Joyce, G.F. A modular, bifunctional RNA that integrates itself into a target RNA. (2003) Proceedings of the National Academy of Sciences of the United States of America. 100(17):9738-43. DOI: 10.1073/pnas.1334190100

+ expand abstract

Kuhns, S.T., Joyce, G.F. Perfectly complementary nucleic acid enzymes. (2003) J. Mol. Evol. 56(6):711-7. DOI: 10.1007/s00239-002-2445-7

+ expand abstract

McGinness, K.E., Joyce, G.F. In search of an RNA replicase ribozyme. (2003) Chemistry & Biology. 10(1):5-14.

+ expand abstract

Paul, N., Joyce, G.F. Self-replication. (2003) Current Biology. 13(2):R46.


Reader, J.S., Joyce, G.F. A ribozyme composed of only two different nucleotides. (2002) Nature. 420(6917):841-4. DOI: 10.1038/nature01185

+ expand abstract

Joyce, G.F. Molecular evolution: booting up life. (2002) Nature. 420(6913):278-9. DOI: 10.1038/420278a


Ordoukhanian, P., Joyce, G.F. RNA-cleaving DNA enzymes with altered regio- or enantioselectivity. (2002) Journal of the American Chemical Society. 124(42):12499-506.

+ expand abstract

Paul, N., Joyce, G.F. A self-replicating ligase ribozyme. (2002) Proceedings of the National Academy of Sciences of the United States of America. 99(20):12733-40. DOI: 10.1073/pnas.202471099

+ expand abstract

Joyce, G.F. The antiquity of RNA-based evolution. (2002) Nature. 418(6894):214-21. DOI: 10.1038/418214a

+ expand abstract

McGinness, K.E., Wright, M.C., Joyce, G.F. Continuous in vitro evolution of a ribozyme that catalyzes three successive nucleotidyl addition reactions. (2002) Chemistry & Biology. 9(5):585-96.

+ expand abstract

McGinness, K.E., Joyce, G.F. RNA-catalyzed RNA ligation on an external RNA template. (2002) Chemistry & Biology. 9(3):297-307.

+ expand abstract

McGinness, K.E., Joyce, G.F. Substitution of ribonucleotides in the T7 RNA polymerase promoter element. (2002) Journal of Biological Chemistry. 277(4):2987-91. DOI: 10.1074/jbc.M108820200

+ expand abstract

Rogers, J., Joyce, G.F. The effect of cytidine on the structure and function of an RNA ligase ribozyme. (2001) RNA. 7(3):395-404.

+ expand abstract

Joyce, G.F. RNA cleavage by the 10-23 DNA enzyme. (2001) Meth. Enzymol. 341:503-17.


Sheppard, T.L., Wong, C.H., Joyce, G.F. Nucleoglycoconjugates: design and synthesis of a new class of DNA-carbohydrate conjugates. (2000) Angewandte Chemie. 39(20):3660-3.


Dai, X., Joyce, G.F. In vitro evolution of a ribozyme that contains 5-bromouridine. (2000) Helv. Chim. Acta. 83(8):1701-10. DOI: 10.1002/1522-2675(20000809)83:8<1701::AID-HLCA1701

+ expand abstract

Joyce, G.F. RNA structure. Ribozyme evolution at the crossroads. (2000) Science. 289(5478):401-2.

+ expand abstract

Sheppard, T.L., Ordoukhanian, P., Joyce, G.F. A DNA enzyme with N-glycosylase activity. (2000) Proceedings of the National Academy of Sciences of the United States of America. 97(14):7802-7.

+ expand abstract

Nowakowski, J., Shim, P.J., Stout, C.D., Joyce, G.F. Alternative conformations of a nucleic acid four-way junction. (2000) Journal of Molecular Biology. 300(1):93-102. DOI: 10.1006/jmbi.2000.3826

+ expand abstract

Santoro, S.W., Joyce, G.F., Sakthivel, K., Gramatikova, S., Barbas CF 3rd. RNA cleavage by a DNA enzyme with extended chemical functionality. (2000) Journal of the American Chemical Society. 122(11):2433-9.

+ expand abstract

Ordoukhanian, P., Joyce, G.F. A molecular description of the evolution of resistance. (1999) Chemistry & Biology. 6(12):881-9.

+ expand abstract

Jaeger, L., Wright, M.C., Joyce, G.F. A complex ligase ribozyme evolved in vitro from a group I ribozyme domain. (1999) Proceedings of the National Academy of Sciences of the United States of America. 96(26):14712-7.

+ expand abstract

Rogers, J., Joyce, G.F. A ribozyme that lacks cytidine. (1999) Nature. 402(6759):323-5. DOI: 10.1038/46335

+ expand abstract

Nowakowski, J., Shim, P.J., Joyce, G.F., Stout, C.D. Crystallization of the 10-23 DNA enzyme using a combinatorial screen of paired oligonucleotides. (1999) Acta Crystallogr. D Biol. Crystallogr. 55(Pt 11):1885-92.

+ expand abstract

Joyce, G.F. The counterforce. (1999) Current Biology. 9(14):R500-1.


Bartlett, P.A., Joyce, G.F. Combinatorial chemistry: the search continues (1999) Current Opinion in Chemical Biology. 3(3):253-5.


Nowakowski, J., Shim, P.J., Prasad, G.S., Stout, C.D., Joyce, G.F. Crystal structure of an 82-nucleotide RNA-DNA complex formed by the 10-23 DNA enzyme. (1999) Nature Structural Biology. 6(2):151-6. DOI: 10.1038/5839

+ expand abstract

Santoro, S.W., Joyce, G.F. Mechanism and utility of an RNA-cleaving DNA enzyme. (1998) Biochemistry. 37(38):13330-42. DOI: 10.1021/bi9812221

+ expand abstract

Joyce, G.F. Nucleic acid enzymes: playing with a fuller deck. (1998) Proceedings of the National Academy of Sciences of the United States of America. 95(11):5845-7.


Joyce, G.F., Orgel, L.E. The origins of life–a status report. (1998) Am Biol Teach. 60(1):10-2.


Joyce, G.F. Evolutionary chemistry: getting there from here. (1997) Science. 276(5319):1658-9.


Joyce, G.F., Still, W.C., Chapman, K.T. Combinatorial chemistry searching for a winning combination (1997) Current Opinion in Chemical Biology. 1(1):3-4.


Santoro, S.W., Joyce, G.F. A general purpose RNA-cleaving DNA enzyme. (1997) Proceedings of the National Academy of Sciences of the United States of America. 94(9):4262-6.

+ expand abstract

Hendrix, M., Priestley, E.S., Joyce, G.F., Wong, C.H. Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance. (1997) Journal of the American Chemical Society. 119(16):3641-8.

+ expand abstract

Bruick, R.K., Koppitz, M., Joyce, G.F., Orgel, L.E. A simple procedure for constructing 5′-amino-terminated oligodeoxynucleotides in aqueous solution. (1997) Nucleic Acids Research. 25(6):1309-10.

+ expand abstract

Tsang, J., Joyce, G.F. Specialization of the DNA-cleaving activity of a group I ribozyme through in vitro evolution. (1996) Journal of Molecular Biology. 262(1):31-42. DOI: 10.1006/jmbi.1996.0496

+ expand abstract

Raillard, S.A., Joyce, G.F. Targeting sites within HIV-1 cDNA with a DNA-cleaving ribozyme. (1996) Biochemistry. 35(36):11693-701. DOI: 10.1021/bi960845g

+ expand abstract

Joyce, G.F. Building the RNA world. Ribozymes. (1996) Current Biology. 6(8):965-7.

+ expand abstract

Tsang, J., Joyce, G.F. In vitro evolution of randomized ribozymes. (1996) Meth. Enzymol. 267:410-26.


Bruick, R.K., Dawson, P.E., Kent, S.B., Usman, N., Joyce, G.F. Template-directed ligation of peptides to oligonucleotides. (1996) Chemistry & Biology. 3(1):49-56.

+ expand abstract

Breaker, R.R., Joyce, G.F. A DNA enzyme with Mg(2+)-dependent RNA phosphoesterase activity. (1995) Chemistry & Biology. 2(10):655-60.

+ expand abstract

Breaker, R.R., Joyce, G.F. Self-incorporation of coenzymes by ribozymes. (1995) J. Mol. Evol. 40(6):551-8.

+ expand abstract

Dai, X., De Mesmaeker, A., Joyce, G.F. Cleavage of an amide bond by a ribozyme. (1995) Science. 267(5195):237-40.

+ expand abstract

Breaker, R.R., Joyce, G.F. A DNA enzyme that cleaves RNA. (1994) Chemistry & Biology. 1(4):223-9.

+ expand abstract

Chakrabarti, A.C., Breaker, R.R., Joyce, G.F., Deamer, D.W. Production of RNA by a polymerase protein encapsulated within phospholipid vesicles. (1994) J. Mol. Evol. 39(6):555-9.

+ expand abstract

Breaker, R.R., Banerji, A., Joyce, G.F. Continuous in vitro evolution of bacteriophage RNA polymerase promoters. (1994) Biochemistry. 33(39):11980-6.

+ expand abstract

Breaker, R.R., Joyce, G.F. Inventing and improving ribozyme function: rational design versus iterative selection methods. (1994) Trends in Biotechnology. 12(7):268-75. DOI: 10.1016/0167-7799(94)90138-4

+ expand abstract

Breaker, R.R., Joyce, G.F. Emergence of a replicating species from an in vitro RNA evolution reaction. (1994) Proceedings of the National Academy of Sciences of the United States of America. 91(13):6093-7.

+ expand abstract

Cadwell, R.C., Joyce, G.F. Mutagenic PCR. (1994) PCR Methods Appl. 3(6):S136-40.


Tsang, J., Joyce, G.F. Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme. (1994) Biochemistry. 33(19):5966-73.

+ expand abstract

Joyce, G.F. In vitro evolution of nucleic acids. (1994) Current Opinion in Structural Biology. 4:331-6.


Lehman, N., Joyce, G.F. Evolution in vitro: analysis of a lineage of ribozymes. (1993) Current Biology. 3(11):723-34.

+ expand abstract

Joyce, G.F. Evolution of catalytic function. (1993) Pure Appl. Chem. 65(6):1205-12.

+ expand abstract

Joyce, G.F. Climbing Darwin’s ladder. (1993) Current Biology. 3(10):703-4.


Lehman, N., Joyce, G.F. Evolution in vitro of an RNA enzyme with altered metal dependence. (1993) Nature. 361(6408):182-5. DOI: 10.1038/361182a0

+ expand abstract

Joyce, G.F. Directed molecular evolution. (1992) Sci. Am. 267(6):90-7.


Cadwell, R.C., Joyce, G.F. Randomization of genes by PCR mutagenesis. (1992) PCR Methods Appl. 2(1):28-33.

+ expand abstract

Beaudry, A.A., Joyce, G.F. Directed evolution of an RNA enzyme. (1992) Science. 257(5070):635-41.

+ expand abstract

Joyce, G.F. RNA today. Molecular Evolution of Introns and Other RNA Elements: a Keystone Symposium, Taos, NM, USA, February 2-8, 1991. (1991) New Biol. 3(6):565-9.

+ expand abstract

Joyce, G.F. The rise and fall of the RNA world. (1991) New Biol. 3(4):399-407.

+ expand abstract

Beaudry, A.A., Joyce, G.F. Minimum secondary structure requirements for catalytic activity of a self-splicing group I intron. (1990) Biochemistry. 29(27):6534-9.

+ expand abstract

Robertson, D.L., Joyce, G.F. Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA. (1990) Nature. 344(6265):467-8. DOI: 10.1038/344467a0

+ expand abstract

Joyce, G.F. Amplification, mutation and selection of catalytic RNA. (1989) Gene. 82(1):83-7.

+ expand abstract

Joyce, G.F., van der Horst, G., Inoue, T. Catalytic activity is retained in the Tetrahymena group I intron despite removal of the large extension of element P5. (1989) Nucleic Acids Research. 17(19):7879-89.

+ expand abstract

Joyce, G.F. RNA evolution and the origins of life. (1989) Nature. 338(6212):217-24. DOI: 10.1038/338217a0

+ expand abstract

Joyce, G.F., Inoue, T. A novel technique for the rapid preparation of mutant RNAs. (1989) Nucleic Acids Research. 17(2):711-22.

+ expand abstract

Joyce, G.F., Orgel, L.E. Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C,A) templates. (1988) Journal of Molecular Biology. 202(3):677-81.

+ expand abstract

Joyce, G.F., Inoue, T. Structure of the catalytic core of the Tetrahymena ribozyme as indicated by reactive abbreviated forms of the molecule. (1987) Nucleic Acids Research. 15(23):9825-40.

+ expand abstract

Joyce, G.F., Schwartz, A.W., Miller, S.L., Orgel, L.E. The case for an ancestral genetic system involving simple analogues of the nucleotides. (1987) Proceedings of the National Academy of Sciences of the United States of America. 84(13):4398-402.

+ expand abstract

Joyce, G.F. Nonenzymatic template-directed synthesis of informational macromolecules. (1987) Cold Spring Harbor Symposia on Quantitative Biology. 52:41-51.


Joyce, G.F. Non-enzymatic template-directed synthesis of RNA copolymers. (1984) Orig. Life. 14(1-4):613-20.

+ expand abstract

Inoue, T., Joyce, G.F., Grzeskowiak, K., Orgel, L.E., Brown, J.M., Reese, C.B. Template-directed synthesis on the pentanucleotide CpCpGpCpC. (1984) Journal of Molecular Biology. 178(3):669-76.

+ expand abstract

Joyce, G.F., Visser, G.M., van Boeckel, C.A., van Boom, J.H., Orgel, L.E., van Westrenen, J. Chiral selection in poly(C)-directed synthesis of oligo(G). (1984) Nature. 310(5978):602-4.

+ expand abstract

Joyce, G.F., Inoue, T., Orgel, L.E. Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates. (1984) Journal of Molecular Biology. 176(2):279-306.

+ expand abstract

Joyce, G.F., Tschirgi, R.D. Automata simulation of the selection process. (1984) BioSystems. 17(1):65-72.

+ expand abstract

Joyce, G.F. The instability of the autogen. (1983) J. Mol. Evol. 19(2):192-4.

+ expand abstract